Kal Naismith makes his 50th appearance for the Hatters in defence and captains the side at Kenilworth Road as the gaffer sticks with the same back-line he trusted in midweek.
Allan Campbell and Henri Lansbury both come into midfield, supporting Pelly-Ruddock Mpanzu whilst Fred Onyedinma makes his first start since the 0-0 draw against Nottingham Forest in November, joined with Cameron Jerome up-front.
Elijah Adebayo is ruled out through injury, so too is Simon Sluga but there is a return to the matchday squad for Harry Cornick, who could feature for the first time since the defeat against Cardiff City in November.
Town: Shea; Bree, Lockyer, Osho, Naismith (C), Bell; Campbell, Mpanzu, Lansbury; Onyedinma, Jerome.
Substitutes: Isted, Potts, Cornick, Berry, Mendes Gomes, Burke, Muskwe
Blackburn: Kaminski; Lenihan (C), Van-Hecke, Whalton; Nyambe, Travis, Johnson, Edun; Zeefuik, Buckley; Gallagher.
Substitutes: Pears, Ayala, Davenport, Rankin-Costello, Butterworth, Chapman, Garrett.
Referee: James Linington