Fred Onyedinma comes into the starting eleven after impressing on his debut in the reverse fixture on the opening day.
Peter Kioso is brought into defence with Tom Lockyer missing out through injury.
The additional changes are in the forward roles, with Danny Hylton and Cameron Jerome both brought into start in place of Henri Lansbury and Harry Cornick respectively, who feature on the bench.
Luton: Shea; Onyedinma, Bree, Kioso, Naismith (C), Bell; Mpanzu, Campbell; Hylton; Jerome, Adebayo.
Substitutes: Isted, Potts, Bradley, Cornick, Snodgrass, Mendes Gomes, Lansbury.
Referee: Thomas Bramall
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