Marvelous Nakamba makes his first start for the club after coming off the bench against Stoke City last weekend.
Gabe Osho keeps his place in defence following the midweek defeat at Grimsby Town as Cody Drameh misses out after picking up a knock in training.
Midfielder Henri Lansbury makes a welcome return to the matchday squad - back on the bench for the first time since sustaining an injury against Sunderland in October.
Joe Taylor is also amongst the substitutes for the second time since joining in the January transfer window.
Luton Town: Horvath; Doughty, Burke, Osho, Lockyer (C), Bell; Nakamba, Mpanzu, Clark; Morris, Adebayo.
Substitutes: Shea, Berry, Woodrow, Lansbury, Campbell, Onyedinma, Taylor.
Referee: Steve Martin