The boss has made two changes from last weekend's draw against Burnley, with Reece Burke brought in for his first league start of the season.
Carlton Morris comes into attack and partners Elijah Adebayo, with Harry Cornick missing out through injury.
Luke Berry and Henri Lansbury are also sidelined, meaning youngsters Louie Watson and Elliot Thorpe are amongst the substitutes after impressing in the Carabao Cup during the week.
Luton Town: Horvath; Bree, Burke, Bradley (C), Potts, Bell; Campbell, Clark, Freeman; Morris, Adebayo.
Substitutes: Macey, Lockyer, Woodrow, Watson, Thorpe, Osho, Jerome.
Referee: Dean Whitestone