Jed Steer makes his Luton debut between the sticks, and Elliot Thorpe starts in midfield, his first involvement in the senior matchday squad.
Reece Burke, Gabe Osho and Fred Onyedinma keep their places from Tuesday's away win against Swansea City, whilst there is a start for Carlos Mendes Gomes in a forward role.
Exciting youngster Josh Neufville makes his return from injury and is on the bench, so too are development squad regulars Ed McJannet and Aidan Francis-Clarke.
Town: Steer; Kioso, Lockyer, Burke, Potts (C), Onyedinma; Osho, Thorpe, Mendes Gomes; Muskwe, Jerome.
Substitutes: Isted, Bree, Cornick, Hylton, Campbell, Bell, Neufville, McJannet, Francis-Clarke.
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