Last season's top scorer Adebayo replaces Cauley Woodrow who started against Blackburn Rovers, absent through injury.
Allan Campbell starts and in doing so makes his 50th Luton appearance in midfield, alongside Henri Lansbury and Jordan Clark.
Reece Burke returns to his former club for the first time, whilst Amari'i Bell is fit and available having travelled away with Jamaica.
Pelly-Ruddock Mpanzu is in the first team matchday squad for the first time since April after building up his match fitness in two Development Squad matches during the international break.
Luton Town: Horvath; Bree, Lockyer, Burke, Potts (C), Bell; Campbell, Lansbury, Clark; Adebayo, Morris.
Substitutes: Isted, Cornick, Mpanzu, Onyedinma, Osho, Jerome, Doughty.
Referee: James Linington