The nine-goal striker missed the win at Rotherham through injury but came off the bench during the second half of the 1-1 draw with Reading last Wednesday, his bravery providing the assist for Carlton Morris' equaliser.
The other change is on the substitutes' bench, where 17-year-old Joe Johnson makes his first matchday squad appearance in the EFL having featured among the subs in the FA Cup replay at Grimsby and travelled with the first team in recent weeks.
Third-placed Hatters are looking to extend their 11-match unbeaten run against Boro, who sit a point behind in fourth place, with both sides already guaranteed a play-off spot.
TOWN: Horvath, Drameh, Lockyer, Bradley (C), Bell, Doughty, Nakamba, Mpanzu, Campbell, Morris, Adebayo.
Subs: Shea, Berry, Lansbury, Clark, Taylor, Freeman, Johnson.
BORO: Steffen, Jones, Giles, Mowatt, Barlaser, Archer, Dijksteel, Howson (C), Crooks, Lenihan, Bola.
Subs: Roberts, Muniz, Akpom, Hackney, Bilongo, Stott, Sykes.
Referee: Graham Scott