Carlton Morris starts in attack with Elijah Adebayo after coming off the bench to score against Swansea City last weekend.
Admiral Muskwe is on the bench, so too is Fred Onyedinma who is included in the matchday squad for the first time this season after recovering from injury.
The Hatters will be looking to secure a second successive league victory in front of the Sky Sports cameras against the league leaders.
Luton Town: Horvath; Bree, Lockyer, Burke, Potts (C), Bell; Campbell, Clark, Freeman; Morris, Adebayo.
Substitutes: Macey, Berry, Woodrow, Muskwe, Onyedinma, Osho, Jerome.
Sheffield United: Foderingham; Basham, Egan (C), Norrington-Davies; Baldock, Berge, Norwood, McAtee, Lowe; N'Diaye, McBurnie.
Substitutes: Amissah, Brewster, Ahmedhodzic, Doyle, Arbiaster, Osula, Jebbison.
Referee: David Webb