Allan Campbell comes in to midfield and replaces Cauley Woodrow who is amongst the substitutes.
Cody Drameh starts for the second match in succession, whilst fellow January arrivals Marvelous Nakamba and Joe Taylor are on the bench.
James Shea is in the matchday squad for the first time since Cardiff in April year, with Jack Walton missing out after picking up an injury in training.
Luton Town: Horvath; Drameh, Burke, Lockyer (C), Bell, Doughty; Mpanzu, Campbell, Clark; Morris, Adebayo
Substitutes: Shea, Berry, Woodrow, Nakamba, Onyedinma, Taylor, Osho.
Stoke City: Sarkic; Wilmot, Jagielka, Fox; Sterling, Baker, Laurent, Tymon; Brown, Gayle, Celina.
Substitutes: Bonham, Campbell, Thompson, Hoever, Smallbone, Macari, Tezgel
Referee: Dean Whitestone