The centre-half replaces Teden Mengi, who drops to a strong looking Hatters bench.
Ross Barkley makes his 250th appearance in the Premier League as the Town aim to make history by being the first newly-promoted Premier League team to score four or more goals in three games in a row.
The Blades are without Brett Brereton-Diaz but Gustavo Hamer – who scored against the Hatters in the play-off final for Coventry – starts. As does former Town loanee Rhys Norrington-Davies.
Town: Kaminski; Ogbene, Doughty, Burke, Osho, Bell; Lokonga, Barkley; Clark, Morris, Adebayo.
Subs: Krul, Berry, Woodrow, Kaboré, Chong, Mengi, Mpanzu, Brown, Townsend.
Sheffield United: Foderingham, Hamer, Archer, Ahmedhodzic, Robinson, Bogle, Souza, Osborn, McAtee, Holgate, Norrington-Davies.
Subs: Amissah, Lowe, Trusty, Brewster, Norwood, Davies, Lacouci, Osula, Brooks.
Referee: Christopher Kavanagh