Town went into this one looking for a second consecutive victory for the first time since August, having overcame Charlton 2-1 on Tuesday night.
Graeme Jones named an unchanged side from that game, with the day itself marking the sixth anniversary since Pelly-Ruddock Mpanzu’s debut against Staines Town in an FA Trophy replay after initially signing on loan from West Ham United.
Town went behind early on as Bryan Mbeumo took advantage of a mix-up between Dan Potts and James Shea, stabbing home from close range.
Harry Cornick looked to get the Hatters back on level terms with ten minutes gone as he was set down the right by Mpanzu – the winger taking it past Ethan Pinnock and getting an effort away from a tight angle, with David Raya being forced to palm it behind for a corner.
Mathias Jensen wasn’t too far away from doubling the lead ten minutes later as Mbeumo found the midfielder on the edge of the box, the summer signing from Celta Vigo curling his first-time effort just wide of the far-post.
Then with 26 minutes on the clock, Shea was forced into a fantastic save as Mbeumo played Watkins in, Shea spread himself well and Watkins couldn’t guide his strike past the ‘keeper.
The former Exeter City man wasn’t to be denied though and made it 2-0 after half an hour as once again he combined with Mbeumo, with Watkins converting from his low cross into the six-yard box.
Three minutes later and Jensen made it three, rolling the ball past Shea into the bottom left corner from ten yards after being picked out by Watkins.
Josh Dasilva got on the scoresheet five minutes before the break as he cut onto his left before bending the ball past Shea into the bottom left corner.
He then doubled his own personal tally for the afternoon as he found the bottom corner with the last kick of the half.
Town’s misery was compounded by an injury to second half substitute Brendan Galloway, who had to be stretchered off in the 65th minute and with the Hatters having made all three changes, had to complete the final 25 minutes with ten men.
Said Benrahma added another to the Brentford tally from the penalty spot with 20 minutes to go after Mpanzu brought down Watkins – sending Shea the wrong way as he rolled it into the bottom right corner from 12 yards.
Dasilva completed his hat-trick in the 87th minute as he fired in from the penalty spot after Dan Potts was adjudged to have brought down Benrahma.
Town are back in Championship action next Saturday as they face Wigan Athletic at Kenilworth Road.
Brentford: Raya, Henry, Pinnock, Jensen (Zamburek 71), Benrahma, Watkins, Dasilva, Jansson (Bech Sorensen 63), Mbeumo, Dalsgaard (Roerslev 76).
Unused subs: Daniels, Thompson, Mokotjo, Oksanen.
Goals: Mbeumo 6, Watkins 30, Jensen 33, Dasilva 40, 45+2, 87, Benrahma 70
Town: Shea, Bree, Pearson, Bradley, Potts, Mpanzu, Tunnicliffe, Shinnie (Galloway 46), Cornick (Bolton 46), Brown (Butterfield 53), Collins.
Unused subs: Sluga, McManaman, LuaLua, Jones.
Attendance: 11,287
Referee: Tony Harrington