Nathan Jones' side know that a win against the Royals will confirm their place in the play-off spots and look to continue their four-game home unbeaten run.
The opposition:
Reading's Championship survival was confirmed despite defeat against Hull City after Peterborough lost at home to Nottingham Forest.
Regardless of the result at Kenilworth Road, the Royals will end the season in 21st position following the six-point deduction they received earlier in the campaign.
John Swift is their top creator with 11 goals and 13 assists but he has been absent from the matchday squad for the last four matches, meaning Reading will rely on striker Lucas Joao to supply the goals - who has 10 in 23 Championship games this season.
Last time we met:
Luton were convincing 2-0 winners when the two sides met at the Select Car Leasing stadium in January, thanks to a Tom Holmes own goal and a second half strike from Allan Campbell.
Highlights from that match can be found via our YouTube channel below...
Follow the action:
There will be no live iFollow stream in countries where the EFL has an overseas broadcast deal because this match is being shown live on Sky Sports.
We are sorry for any inconvenience this causes our loyal supporters, but unfortunately we have no control over the selection of our matches for live coverage.
UK-based supporters will NOT be able to watch the match on iFollow. However, fans can tune into Simon Pitts’ match commentary by purchasing an audio pass for a single game or a month. Prices for both options can be found HERE.
Ref watch
Referee: Jeremy Simpson
Assistant Referees: Robert Hyde and Lee Venamore
Fourth Official: Chris Pollard
The man in the middle on Saturday is Jeremy Simpson. He took charge of Luton’s 2-1 away defeat against Middlesbrough in March and has officiated 34 matches this season, showing 127 yellow cards and seven reds in the process.