Before the international break, Town suffered a first home defeat in seven matches at the hands of Stoke City and consequently dropped down to 11th position.
However, victory at the Kiyan Prince Foundation stadium could see them move back into the play-off places, at the expense of Friday's opposition.
The opposition:
Queens Park Rangers are flying high in the Sky Bet Championship after a good start to their seventh successive campaign in the second division.
In their last match, Ilias Chair’s late goal helped them to victory against Blackburn Rovers, ending a run of three games in all competitions without a win.
Last time we met:
QPR earned the bragging rights against the Hatters last season with victory home and away.
Charlie Austin opened the scoring when the two sides last met, before Kiernan Dewsbury-Hall equalised just before half-time. The hosts regained the lead through Stefan Johansen before Albert Adomah secured the points at the Kiyan Prince Foundation Stadium.
The wait for a victory against the Hoops dates back to 2007 for Luton, something the team will hope to change on Friday night.
Follow the action:
Because this match is being broadcasted live on Sky Sports Football, supporters will not be able to watch via iFollow Hatters, but you can still listen along to Simon Pitts’ match commentary as per usual.
Ref watch
Referee: Matt Donohue
Assistant Referees: Philip Dermott and Paul Hodskinson
Fourth Official: Dean Whitestone
The man in the middle on Friday night is Matt Donohue, who last took charge of the Hatters in the 2-1 home defeat against Barnsley earlier this year.
He has officiated 11 matches so far this season, dishing out 37 yellow cards and four reds.