Picking up two points from their last two matches, Nathan Jones' side will be searching for a vital win at the John Smith's Stadium.
The opposition:
Huddersfield, alike the Hatters, are flying high in the Sky Bet Championship contending for a spot in the play-off places.
A run of two defeats on the spin was ended after beating Hull at the start of the month, and they will turn to creative outlet Sorba Thomas and top scorer Danny Ward to try and keep that positive run going.
Last time we met:
The two sides played out a hard-fought draw at Kenilworth Road in October. History suggests another evenly matched game on Monday evening with the last three matches ending a draw, whilst Huddersfield have the better head-to-head record with 12 wins compared to Luton's nine.
Highlights of the reverse fixture this season can be found here...
Follow the action:
Live coverage on Sky Sports means there will be no live iFollow stream in countries where the EFL has an overseas broadcast deal.
Ref watch
Referee: Geoff Eltringham
Assistant Referees: Shaun Hudson and Paul Hodskinson
Fourth Official: David Webb
The man in the middle on Monday night is Geoff Eltringham, who recently took charge of the Hatters' 2-1 home win against Bristol City in January.
Eltringham has officiated 28 games in total this season, dishing out 118 yellow cards and five reds.