After progressing past Harrogate Town last month, Town will hope to reach the fifth round for the first time since 2013.
The opposition:
Cambridge produced an FA Cup upset as they knocked out Premier League side Newcastle United in the previous round.
Joe Ironside scored the winner that day and has 12 goals to his name in all competitions, a striker that Town's defence will have to keep an eye on should they have ambitions of progressing.
Last time we met:
The last meeting between the two sides stretches back to 2018, a 1-1 draw away at the Abbey Stadium.
The reverse fixture that season saw the Hatters win by seven goals - with Olly Lee scoring from inside his own half and Danny Hylton bagging a hat-trick.
Highlights from that day can be found via our YouTube channel below...
Follow the action:
Tickets for this fixture are sold out meaning the only way to watch in the UK if you do not have a ticket is via the BBC Red Button.
Commentary from Simon Pitts will also be available via iFollow and you can purchase an audio pass HERE.
Ref watch
Referee: Josh Smith
Assistant Referees: Graham Kane and Craig Taylor
Fourth Official: Sam Purkiss
The man in the middle on Saturday is Josh Smith who last took charge of the Hatters in the 4-0 defeat against Cardiff in November 2020.
He has officiated 28 matches so far this season, dishing out 106 yellow cards and three reds in the process.