Teden Mengi is not fit to feature but Reece Burke is fit to face the reigning champions.
With Issa Kaboré out the Hatters are once again stretched, the Town are young on the bench with 16-year-old Christian Chigozie named among the substitutes. January transfer arrival Taylan Harris is included in the Hatters squad for the first time since signing from Reading.
City field five players who started in their 3-3 draw against Real Madrid in the Champions League.
Town: Kaminski; Onyedinma, Doughty, Hashioka, Burke; Barkley, Berry, Clark; Chong, Townsend, Morris.
Subs: Shea, Krul, Woodrow, Mpanzu, Johnson, Harris, Chigozie, Nelson, Piesold.
Manchester City: Ederson, Dias, Kovacic, Haaland, Doku, De Bruyne, Alvarez, Gvardiol, Akanji, Nunes, Lewis.
Subs: Ortega, Walker, Ake, Grealish, Rodri, Silva, Gomez, Foden, Bobb.
Referee: John Brooks