Three of the four that start all made an impact as a substitute in the 3-2 defeat in the Premier League, with Chiedozie Ogbene, Carlton Morris, who captains the side, and Tahith Chong all lining up against the Trotters.
In the fourth change, goalkeeper Tim Krul makes his first appearance in goal since the Carabao Cup game at Exeter.
For the visitors, former Hatters striker Cameron Jerome is named among the substitutes.
Town: Krul; Ogbene, Doughty, Osho, Mengi, Bell; Lokonga, Barkley; Chong, Adebayo, Morris.
Subs: Kaminski, Andersen, Berry, Woodrow, Kaboré, Mpanzu, Clark, Townsend.
Bolton: Baxter, Santos, Sheehan, Charles, Dacres-Cogley, Adebayejo, Forrester, Toal, Maghoma, Dempsey, Williams.
Subs: Coleman, Iredale, Thomason, Bodvarssson, Morley, Ashworth, Jerome, Matheson, Lewis.
Referee: Andy Madley