Defender Reece Burke makes his first Town appearance since the 2-2 draw at Nottingham Forest in October while Pelly Ruddock Mpanzu starts to make his 389th appearance in Luton colours.
Striker Carlton Morris, fresh from his equaliser at Turf Moor, starts, while Tim Krul gets the nod in goal and Tahith Chong starts in midfield.
Town: Krul; Ogbene, Doughty; Mengi, Osho, Burke; Mpanzu, Barkley, Chong, Clark; Morris.
Subs: Kaminski, Potts, Berry, Woodrow, Adebayo, Brown, Giles, Bell, Townsend.
Bolton: Baxter, Thomason, Santos, Sheehan, Charles, Dacres-Cogley, Adeboyejo, Forrester, Toal, Maghoma, Ashworth.
Subs: Coleman, Iredale, Bodvarsson, Morley, Dempsey, Jerome, Matheson, Andreucci, Lewis.
Ref: Thomas Bramall