Jacob Brown, after scoring in his last two matches coming off the substitutes’ bench, is rewarded with a start, replacing Chiedozie Ogbene in attack.
Striker Elijah Adebayo makes his first start since the home defeat to West Ham, taking the place of Carlton Morris, who drops to the bench.
There is also a return to the starting XI for Andros Townsend, while Alfie Doughty recovers from a hip injury to start after missing the game at Brentford on Saturday. Tahith Chong drops to the bench but skipper Tom Lockyer misses out completely.
Pelly Ruddock Mpanzu, making his 386th appearance, captains the side.
Town: Kaminski; Kaboré, Doughty, Mengi, Osho, Bell; Mpanzu, Barkley; Townsend, Brown, Adebayo.
Subs: Krul, Ogbene, Berry, Morris, Chong, Clark, Giles, Johnson, Nelson.
Arsenal: Raya, Saliba, White, Gabriel, Saka, Odegaard, Jesus, Martinelli, Kiwior, Havertz, Rice.
Subs: Ramsdale, Nketiah, Soares, Trossard, Jorginho, Nelson, Elneny, Zinchenko, Walters.
Referee: Sam Barrott