The midfielder is joined in the starting XI by former Tottenham winger Andros Townsend, who lines up at right-wing-back.
Joe Johnson, fresh from signing his new contract is among the substitutes, as is Fred Onyedinma in his first involved for the Hatters since the play-off final in May.
Town: Kaminski; Townsend, Doughty, Mengi, Burke, Kaboré; Mpanzu, Barkley, Berry; Chong, Morris.
Subs: Shea, Krul, Clark, Hashioka, Onyedinma, Johnson, Nelson, Piesold, Woodrow.
Tottenham: Vicario, Dragusin, Son, Bissouma, Maddison, Werner, Romero, Kulusevski, Porro, Sarr, Udogie.
Subs: Austin, Hojbjerg, Richarlson, Royal, Lo Celso, Johnson, Bentancur, Davies, van de Ven.
Referee: Jarred Gillett